The paper introduces a proposal for an automated magnetic resonance (MR) image segmentation called Case-Based Genetic Algorithm Location-Dependent Image Classification (CBGA-LDIC) and presents its evaluation results. This method finds an appropriate cell set towards efficient image segmentation. It uses location-dependent image classification (LDIC), which is integrated by genetic algorithm (GA) combined with case based reasoning (CB). LDIC is a local heuristic, which defines multiple location-dependent classifiers. Each classifier is trained by Gaussian mixture model. CBGA-LDIC decomposes the whole image into some cells, makes a set of cells, and then trains classifiers. The method is applied to knee bones, because these bone formations are similar in their location. Therefore, good combinations of cells are useful and stored in case bases. To show, that this method produces better results that other ones and to find optimal parameters, some experiments have been performed and their results are presented in this paper.