In this paper, study the influence of anti-stripping agent on the mesoscopic strength of basalt asphalt mixture in seasonal frozen region under different states and temperatures by experiments. Meanwhile Accurately and objectively evaluate the characteristics on engineering performance of two kinds anti-stripping agents. Results show that anti-stripping agent improves the mesoscopic strength of basalt asphalt mixture. The research results can provide theoretical basis for the design and construction of basalt asphalt pavement, which is suitable for Jilin Province and Jilin Province with the same weather conditions or engineering background.