The carrier frequency between 4.4 GHz to 4.6 GHz is a promising spectrum for 5G mobile communications. In this paper, the MIMO channels at 4.6 GHz are measured and analyzed with massive MIMO TDD prototype. The DoA in uplink and downlink channels are investigated, with which channel reciprocity is analyzed. The measured scenarios cover LOS, NLOS, and blockage channels in outdoor microcell environment. Channel calibrations via air interface are performed in transmit antennas and receive antennas in order to estimate the spatial spectrum of the channels. DFT and MUSIC algorithms are presented for DoA estimation. Based on the channel measurements and analysis, we find that the MIMO channels are well symmetric in terms of channel impulse response profile and DoA in downlink and uplink. The channel symmetry, however, is weakened for blockage and NLOS, particularly in case of near-field blockage and full-blocked NLOS. These findings are beneficial information to the design of 5G systems.