Optimized configuration method of transformer magnetic bias treatment devices is proposed on the basis of multi-indexes comprehensive evaluation. First, based on analyzing of the mechanism of transformer magnetic bias and its influence factors, the paper constructs a satisfactory optimization model. Followed, it is calculated about satisfaction degree and urgency degree of each substation influenced by transformer magnetic bias. Then the minimal set of substations that need to be treated is extracted by iterative algorithm. Finally, an example is given and the application effect of optimized configuration method is also summarized. With the applying of the optimized configuration method, the treatment devices of transformer magnetic bias can be rational distribution, and the control area by single treatment device can be extended. Moreover, equipment utilization can be improved and the investment of treatment device can be reduced.