The paper presents some advanced techniques to improve the calibration and pre-processing of the TASI-600 thermal hyperspectral sensor acquired by the Italian National Research Council — Institute of Methodologies for Environmental Analysis (CNR-IMAA). TASI-600 sensor has 32 spectral bands in the 8.0–11.5 μm spectral range, with a swath of 600 pixels and an IFOV of 2 mrad. The sensor is provided with a custom Stirling Cycle cooled MCT detector (HgCdTe) specifically designed for the TASI-600 and the system includes licensed pre-processing software to radiometrically correct the data. Nevertheless, after the TASI became operative, there was evidence of some artifacts induced in the calibrated images by the preprocessing procedures. Among them, blinking pixels, calibration artifacts and sporadic striping noise required the development of dedicated correction procedures.