Personalized drug dosage is crucial to ensure op- timal benefit in patient’s treatments. Therefore, many efforts are done in developing integrated, low-cost and portable point- of-care sensing systems able to continuously monitor the drug concentration. To satisfy this request, a portable multi-channel system is here presented and validated. The system is able to run different electrochemical techniques independently on each channel. Thanks to the flexibility of the system it is possible to configure it for different medical applications, as for anesthesia practices. The Raspberry Pi has been chosen as main control unit since it offers high performances and excellent features with low- costs.