In the process of reentry trajectory optimization of glide hypersonic vehicle, a new adaptive detection point pseudospectral method based on detection point is proposed to solve the problem of no-fly zone constraints between adjacent collocation points. This method adaptively adjusted the number of discrete subintervals and the number of collocation points in the interval according to the maximum allowable error, and adaptive adjustment occurred in the number of the detection points according to the no-fly zone constraints. And the result was obtained by the sequential quadratic programming. Simulation results show that the optimal design of a trajectory with 3∼5 seconds, the calculation efficiency is higher; no-fly zone constraints satisfaction are improved between the collocation points, and the optimized trajectory is safer and more reliable; compared with the integral result, the maximum relative error is 0.13%. The algorithm has high precision.