This paper presents a new coupling-based robust control for generic reentry vehicles. First of all, the error dynamics of generic reentry vehicles is obtained based on backstepping technique. Then, a disturbance observer is proposed to estimate and compensate the lump disturbances. Finally, a robust coupling-based control scheme is proposed combining with disturbance observer, and the closed-loop stability is guaranteed through the Lyapunov theory. The aerodynamic parameters perturbation and actual actuator constraints are considered in numerical simulations, and the results demonstrate the validity of the control method in this paper.