Taxi dispatch is a critical issue for taxi company to consider in modern life. This paper formulates the problem into a taxi-passenger matching model and proposes a parallel ant colony optimization algorithm to optimize the model. As the search space is large, we develop a region-dependent decomposition strategy to divide and conquer the problem. To keep the global performance, a critical region is defined to deal with the communications and interactions between the subregions. The experimental results verify that the proposed algorithm is effective, efficient, and extensible, which outperforms the traditional global perspective greedy algorithm in terms of both accuracy and efficiency.