This paper presents the design and optimization of a 183 GHz profiled corrugated horn for a Microwave Humidity Sounder using Adaptive Neuro-Fuzzy Inference System (aNFIS). The theory and the process of designing antenna using ANFIS are discussed briefly. The return-loss and the radiation patterns of a horn, designed using ANFIS are compared with the results obtained using commercially available simulator and they were found in close agreement. It was observed that the horn can be designed using ANFIS based approach even with limited computational resources and very less processing time.