One of 5G communication typical scenarios is machine-to-machine communication with large number of devices, which proposes new requirements for uplink transmission. Filter bank multi-carrier with offset quadrature amplitude modulation (FBMC/OQAM) is one of the popular nonorthogonal waveform candidates for 5G transmission. In this paper, FBMC/OQAM and cyclic prefix OFDM with single antenna settings are comprehensively evaluated and compared in uplink transmission form four aspects: power spectral density, timing and frequency misalignments, guard bands between adjacent users and time efficiency. At last, our comparison results show that FBMC is more suitable for 5G uplink multi-user asynchronous transmissions than CP-OFDM.