This work investigates how the aging of lithium-ion batteries is influenced by several less well-known properties of different vehicle drive profiles. It is demonstrated that the RMS current value is a statistically significant aging factor for the case of dynamic drive profiles, extending the results of previous work that focused on steady-state discharge current waveforms. In addition, a quantitative analysis procedure is developed to facilitate the separation of aging factors and to analyze their individual and mutual effects. Strong statistical evidence is presented to support the importance of the interaction between the RMS current value and the battery discharge temperature on aging characteristics. The impact of these outcomes on designing battery systems that include provisions for reducing the AC content of the battery current as a function of the battery operating temperature are discussed.