It is a great pleasure and honor to greet you to the annual conference, 2016 IEEE International Conference on Systems, Man, and Cybernetics (SMC 2016) at Budapest, Hungary. SMC 2016 is the flagship conference of the IEEE Systems, Man, and Cybernetics Society. It provides an international forum for researchers and participants to report up-to-the-minute innovation and development, summarize state-of-the-art, and exchange ideas and advances in all aspects of systems science and engineering, human-machine systems, and cybernetics. SMC2016 is dedicated to the Hungarian born John von Neumann “a Pioneer of Modern Computer Science”. In honor of him, the theme of the conference is “A theory that transformed the world to a Cyberspace”. We hope that this conference provides a good platform for valuable meeting and you will enjoy Budapest as well, which is frequently called the “Little Paris of Middle Europe” since it has rich historical and cultural heritage.