DNA (deoxyribonucleic acid), is hereditary in humans which stores the information as a code made of four chemical base: A (adenine), C (cytosine), T (thymine) and G (guanine). DNA bases pair up with each other, A with T and C with G, to form units. Each base is also attached to a sugar and a phosphate molecule, which are arranged in two strands and form a spiral called a double helix, together are called a nucleotide. The security of the medical images and its related data is the research area which is to be concentrated in today's era. Security in the medical image can be done by hiding patients related data into another image and transfer it safely to a defined location. Cryptography along with steganography are two popular methods available to impose security. This proposal focuses on the approach of using a DNA images as a native cover, which is to be extract from an unobtrusive cover image. The security and performance concern of the existing algorithm is to be evaluated and design a more suitable algorithm on same basis. Capabilities of both algorithms are verified against many parameters such as security and performance. For Cryptography, new symmetric key algorithm is used as Modified Symmetric Key (MSK). For image based steganography, Least Significant Bits (LSB) techniques has been proposed to enhance the security of the communication.