In this paper, an optimization-based procedure for performance comparison of alternative compact UWB antenna topologies is discussed. Our approach allows for fast assessment of compact antenna performance by identifying the best possible trade-offs between the antenna size and its reflection responses. Analysis of such Pareto-optimal designs obtained for various antenna topologies allows for their fair comparison, particularly in terms of the minimum size they can be designed for (assuming acceptable reflection response levels) or the best attainable reflection characteristics. The multi-objective optimization algorithm utilized in this work exploits sequential domain patching technique and variable-fidelity EM simulation models. The proposed approach is demonstrated using two topologies of compact UWB monopole antennas.