Air pollution is one of the most concerned problems both for researchers and the public. In this study, we collected long-term observation of mass concentrations of PM10, PM2.5, and other gaseous pollutants in Wuhan, China, including sulphur dioxide (SO2), nitrogen oxide (NOx), from 2011 to 2014. The time series analysis is utilized to analyze the long-term trends of particulate matter (PM) and gaseous pollutants. Results show that the concentrations of PM and SO2 have the trends to decrease due to the efforts of emission reduction and energy optimization. However, with the increase number of motor vehicles, the upward momentum of NOx will not be reduced. The joint efforts of the government and the public are still needed. And, the seasonal characteristic for most pollutants is obvious. At last, we demonstrate the linear relationship between PM10 and PM2.5, and reveal that PM2.5 serves as the primary pollutant in Wuhan region, which should be paid more attention.