A CMOS image sensor architecture is presented that uses an extra level of parallelism and thermal and 1/f noise suppression techniques to achieve both low-light detection and a high frame rate. By adding the row-parallel readout ADCs, the conversion speed is improved by more than twice compared to the conventional top-bottom parallel ADC structure. The thermal and 1/f noise is reduced by combining the intrinsic oversampling of the incremental sigma-delta ADCs and the 1/f noise suppression through the source-follower inversion-to-accumulation method. A 128×128 pixel CMOS image sensor with 5mm×5mm chip dimension has been fabricated in a 180nm CIS technology to validate the architecture. The measured noise is 128µV at the equivalent line time of 2.5µs in digital CDS mode, with the total power consumption of 60mW. In the 1/f noise suppression mode with the same condition, the total noise is as low as 118 µV.