Aggressive speed roadmap for consumer product requires performance boost with power management policies under wear-out, process, voltage and temperature variations. In-Situ timing Monitors is a promising solution for adaptive wear-out management solutions and more generally it helps minimize all voltage margins related to manufacturing variations and operating conditions. A complete insertion of monitor scheme in industrial digital flow is presented. The impact of arbitrarily selection of path under monitoring is widely discussed. The coverage (amount of path monitored in reference PVT vs worst critical path monitored in arbitrary PVT) is at first order dependent on voltage. Measurement of time detection windows of inserted monitors is presented for 28FDSOI and 40nm bulk technologies from ST-Microelectronics. In addition, a counter of ISM warnings is implemented and measurements are shown for different workloads, temperatures, frequency operations and ISM time windows on large samplings.