A novel 4-times voltage multiplier rectifier with smart Time-Division-Multiplexing (TDM) control strategy for high step-up converters is proposed in this paper. Based on the proposed TDM control strategy, two full-wave voltage doubler rectifiers can be combined to realize the proposed 4-times voltage multiplier rectifier. The novel 4-times voltage multiplier rectifier and TDM control strategy can reduce transformer turn ratio and transformer size for high step-up converters and also reduce voltage stress for the output capacitors and rectifier diodes. Simulations and experiments are conducted in this paper to validate the proposed 4-times voltage multiplier rectifier with smart TDM control strategy for high step-up converters. The results show that the proposed smart TDM control strategy has great potential to be used in high step-up converters.