The paper deals with designing and implementation of Smart Grid with designing of power quality measurement software in these networks. Various renewable sources represented by small hydropower plant, photovoltaic power plant and wind power plant are integrated in the designed scheme of Smart Grid. A part of the real network model in laboratory environment is controlling and evaluating SCADA system which was designed in LabVIEW program. This system provides real-time control of power switching relays, obtains information about their status and performs three-phase measurement. The basic system displays information about voltage, current, and total harmonic distortion. SCADA system can perform detailed power quality measurement in individual points. The system supplies three types of customers, namely industrial zone, a city and two villages. The entire system is connected into a mash-grid structure. Several analyses and measurements were carried out for the given structure in order to obtain results for optimal operation of the network focusing on the power quality in Smart Grid.