Most research works of interference alignment (IA) focus on the symmetric networks. When the difference of path loss is considered in asymmetric networks, topology management (TM) needs to be carefully designed for IA-based interference networks, through separating the network into an IA subnetwork and some spatial multiplexing (SM) subnetworks. Nevertheless, the resource allocation problem has been largely ignored in previous works on TM for IA-based networks. In this paper, antenna selection (AS) and power allocation (PA) are exploited to further improve the performance of IA- based networks. We first apply AS technique to the IA subnetwork, through fully utilizing the redundant antennas. Then the transmitted power is allocated among the transmitters of both the IA and SM subnetworks, to optimize the spectrum efficiency. Based on these two techniques, the joint optimization of AS and PA is developed through a stepped resource allocation optimization strategy to further improve the performance with low computational complexity. Simulation results are presented to show the effectiveness of the proposed schemes.