This work deals with the development of an electronic system for portable electrochemical sensing. The presented acquisition module is able to operate in amperometry, voltammetry and potentiometry modes. The system can be optionally linked to a mobile readout device (as smartphone, tablet, etc.) using the Smart Bluetooth 4.1. The system is suitable for a wide range of portable and wearable applications spreading from biomedical to environmental monitoring. The system features small sizes, small weight, and ultra-low power consumption.