Hemodialysis machine, regarded as an important clinical application of regular dialysis therapy, is a necessary equipment for the treatments of uremia patients as well as blood poisoning patients. Currently, medical device manufacturers as well as metrology measurement agencies in China usually use hemodialysis machine detectors as the commonly accepted functional calibration equipment for hemodialysis machines. So far, in China, there is no experimental protocol or devices can be used to test the accuracy and reliability of hemodialysis machine detectors, therefore, a set of new metrological apparatus with the name of hemodialysis machine detectors calibration equipment, is on the way of designing in order to make a traceable system for the calibration or verification of hemodialysis machine detectors. Principles and some research methods of this calibration equipment will be discussed in this paper.