In an attempt to make our cities more sustainable and resource efficient, we are transforming them into what we now call Smart Cities. This transformation is heavily dependent on ICT, where a huge network of interconnected sensors and other devices is deployed to monitor many aspects of urban life in real-time. Recently, Solanas et al. [1] introduced the concept of Smart Health (s-Health) in which the resources of a smart city are exploited to facilitate the provision of healthcare services to citizens. In this position paper we explore the potentials of s-Health in stress management, providing a conceptual framework which could be used not only to monitor the stress level, but to provide more advanced ICT intervention.