Timely detection of targets continues to be a relevant challenge for hyperspectral remote sensing capability. The automatic target-generation process using an orthogonal projection operator (ATGP-OSP) has been widely used for this purpose. Hyperspectral target-detection applications require timely responses for swift decisions, which depend upon (near) real-time performance of algorithm analysis. Reconfigurable field-programmable gate arrays (FPGAs) are promising platforms that allow hardware/software codesign and the potential to provide powerful onboard computing capabilities and flexibility at the same time. In this paper, we present an FPGA implementation for the ATGP-OSP algorithm. Our system includes a direct memory access module and implements a prefetching technique to hide the latency of the input/output communications. The proposed method has been implemented on a Virtex-7 XC7VX690T FPGA and tested using real hyperspectral data collected by NASA’s Airborne Visible Infra-Red Imaging Spectrometer (AVIRIS) over the Cuprite mining district in Nevada and the World Trade Center in New York. Experimental results demonstrate that our hardware version of the ATGP-OSP algorithm can significantly outperform a software version, which makes our reconfigurable system appealing for onboard hyperspectral data processing.