Assessing and optimizing the functionality of the various microelectronic components of the powertrain of battery propelled vehicles, is a crucial pre-request to further develop and make sure the electronics could fit well in practical applications. For this purpose, dedicated modeling, simulation and analysis methods have been developed. First parameterizable multi-disciplinary system models, covering among others electrical, digital and magnetic domains, with special emphasis on the description of analog parasitic, are developed. The typical values as well as value ranges for the parameters which affect the system performance are considered. Then the simulations are executed with the application of Experiments Planning method. Statistical and metamodeling strategies are adopted to derive metamodels to visualize, analyze and interpret the simulation results, especially the sensitivity of the system behavior to its parameters. A Battery Management System has been chosen to demonstrate the methods. More specifically, the Active Balancing of a 12-series Lithium-Ion cells battery module is investigated: the sensitivity of the energy transfer to the system and component parameters is derived and representative metamodels are created.