Real-time monitoring of vital signs from persons during exercises is useful from the medical, healthcare and sports physiological points of view. In professional team sports, physical trainers or technical coaches want to manage the physical conditions of athletes during exercise training in the grounds, on the other hand, in elementary and junior high schools, teachers want to take care of schoolchildren during physical training. In realization of the vital signs monitoring, there are three technical problems to be solved. The first is how to accurately sense vital signs, the second is how to reliably transmit them by wireless, and the third is how to identify factors effective for disease screening, injury prevention, performance analysis and talent identification. In this paper, we present the necessity of real-time monitoring of vital signs from persons during exercises, introduce solutions for the problems which we have so far worked out, and point out remaining technical problems.