Based on the design of traditional noninvasive oximeter and the method of near infrared spectroscopy measurement, a wireless pulse oximeter is designed with the use of Bluetooth 4.0 low energy technology, combining smart mobile APP with hardware. The oximeter uses an Radio Frequency (RF) integrated chip CC2540 to control red light LED and infrared red light LED lighting in turn, sample pulse wave signal with Analog-to-Digital Converter (ADC) and package data in a custom format, then sent data to smart mobile with Bluetooth 4.0 BLE. The mobile terminal processes pulse wave signal with digital algorithm, calculates the value of oxygen saturation (SpO2) and pulse rate, and finally presents them along with pulse wave graph visually through the smart mobile APP interface. At the end of the article, the feasibility of the system is verified through practical test.