Biomedicai engineering deals with the application of various concepts of engineering in the field of medicine and biology mainly for health care purposes thereby improving patients quality of life. Out of the various techniques, the primary focus is to develop a reliable and optimized technique for electro simulation of heart. The present work deals with an improvement in the design of control system for regulating the heart rate of pacemaker in an efficient way. In the proposed method, the performance of the controller is improved by a performance improvement loop incorporating MIT Rule and Delta Rule along with Adaptive Correction factor. Simulation results were performed on the developed cardiovascular system of humans and results show that the proposed PID controller produces superior control performance than conventional PID controller. Simulations were done in Matlab/Simulink.