Noise, found in all types of instrumentation and signal processing systems, has been a great challenge to tackle, especially, in biomedical signal processing tasks. Often, low-frequency and low power measurement signals are used in biomedical signal applications. This work is aimed at modeling and developing a simple, efficient, and inexpensive front end signal conditioner applying the cowpox approach to low-power analog signal measurements. We focus here on the simulation and implementation of a signal conditioner for the evaluation of its feasibility and efficiency based on the cost and accuracy constraints. As briefly outlined below, this article can serve as a model for facilitating the construction of semi-digital filters that can be applied to denoising of signals with low-frequency and very weak amplitude levels.