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This paper proposes the regenerative amplifier based on the Colpitts oscillator topology. The positive feedback amount was optimized analytically in the circuit design. The proposed regenerative amplifier was fabricated in 65 nm CMOS technology. The measurement results showed 28.7 dB gain and 6.4 dB noise figure at 2.55 GHz while consuming 120 μW under the 0.5-V power supply.