A desktop based real time oxygen auto-ventilation and gas monitoring system is proposed for home care respiratory application. The system consists of four sub-systems: oxygen monitoring system, oxygen ventilation system, gas monitoring system, and data transfer system. An oximeter transmits arterial oxygen saturation level and heart rate to the desktop unit via Bluetooth. Based on the oxygen saturation level, a flow rate is computed on the desktop. The computed flow rate is used to regulate the supply of oxygen from the oxygen generator to the patient. In addition, the gas temperature and gas pressure is monitored in real time. The system was able to monitor the patient's oxygen saturation, patient's heart rate and the gas condition at frequency of 1 Hz. Increased heart rate and low oxygen saturations are signs of respiratory distress, which this system uses to prompt oxygen flow. By matching oxygen supply to clinical need, the system has the potential to improve the home care and quality of life of patients with chronic respiratory disorders who are frequent desktop users.