Current methods in treating chronic wounds have had limited success in large part due to the open loop nature of the treatment. In turn, we have created a localized smart wound dressing platform that will allow for real time data acquisition of oxygen concentration at the wound site. This will serve as the first leg of a feedback loop for a fully optimized treatment mechanism tailored to the individual patient. A flexible oxygen sensor was synthesized with high sensitivity and linear current output. With a series of off-the-shelf electronic components including an analog front end, a microcontroller, and wireless radios, an integrated electronic system with data read-out and wireless transmission capabilities was assembled in a compact package. The front-end amplifier is fully programable with numerous internal gains, enabling the read-out system to monitor a wide range of oxygen concentrations. Using an elastomeric material, a bandage with exceptional flexibility and tensile strength was 3D-printed without sacrificing a low overall modulus. Our integrated, flexible platform is the first step toward providing a self-operating, highly optimized remote therapy for chronic wounds.