This paper presents a de-embedding methodology based on transfer function concepts applicable to probed measurements performed on PoP configurations for a highperformance SoC. This methodology is applied for recovering signals at the receiver's IO pads in a mission-mode configuration, from those measured at probe points in a probing configuration in real-time. It also offers physical insight into the interposer's performance thus allowing for solution space exploration and meaningful comparisons of the two different interposer technologies to be presented.