Neuro-spike communication is an important branch of molecular communications and has attracted much attention recently. Seminal works on the analyses of signal processing and channel models for the synaptic communication have recently been carried out. However, these works do not consider interference. In this paper, we propose an interference model for synaptic channels with particular focus on InterSymbol Interference (ISI) and Single-Input Single-Output (SISO) channel. We have investigated the overlapping between the two consecutively signals which are sent from a presynaptic terminal to a postsynaptic terminal and their interferences. Furthermore, important parameters of synaptic communication channel that are related to the ISI are also analyzed. The relationship between channel rate region and ISI is also studied.