3D display can reflect the image depth information and make the image present stereoscopic sensation to improve the medical imaging effect and diagnosis accuracy, if the technology can be used in image guide surgery to diagnose lesion location. This paper will mainly elaborate some advanced naked eye 3D display technologies — multi-view auto-stereoscopic display technology, integral photography 3D display technology and holographic 3D display technology. At last, image guide surgery based on interactive 3D navigation system is proposed. Meanwhile, this paper indicates the trend of medical imaging fields.