Tongue tassel line is an important part of the content of tongue diagnosis, however, there's few works about tongue saliva accumulation in ancient and modern tongue diagnosis literature. As the accelerated pace and increased pressure of modern life, the population in anxious state is increasing and anxiety disorder incidence rate is rising gradually. Combing the relevant clinical reports of tongue tassel line, this paper aims to discuss the etiology and pathogenesis, summarize its application in clinical diagnosis and prevention of anxiety disorder.