This paper investigates performance of the constrained partial group decoding (CPGD) technique in interference channel (IC) environment. It demonstrates the CPGD capability to manage and mitigate interference comparing with other interference mitigation schemes which are based on interference alignment strategy; this comparison is carried out for MIMO interference channel. Numerical results show that CPGD achieves one of the highest capacities comparing to other considered schemes. As well, evaluation of bit error rate (BER) using very long low density parity-check (LDPC) codes demonstrates the competency of the CPGD which significantly outperforms the other techniques. This makes the CPGD a promising scheme for interference mitigation for the next generation of wireless communication systems; especially, if we take into account that CPGD is only based on receive-side processing; and that means, there is no need for any overwhelming feedback in such a system. Also, and more importantly, if we keep in mind the reduction of its required computational complexity, due to its complexity controlling feature, i.e., by it's flexibility to limit the group size of the jointly decoded users, comparing with the huge computational complexity of the iterative multi- user detection (MUD) schemes, as interference alignment approach.