The recent digital transition of TV broadcasting has created new opportunities for wireless usage for voice, video and data services in these newly released bands (known as TV white spaces). Some possible wireless technologies that can be deployed in this new spectrum are LTE and Wi-Fi. In this paper, we conduct an in-depth analysis of the physical layer performance of LTE and Wi-Fi in the presence of cross-technology interference. We propose a physical layer simulation framework in order to co-simulate the link level performance of LTE and Wi-Fi and show the impact of different interference patterns on the error rate. Our results show that the Wi-Fi performance is slightly exacerbated in the presence of LTE interference (compared to similar Wi-Fi interference). We also show that LTE pilot boosting has negligible impact on Wi-Fi performance. Finally, we also show the impact of Wi-Fi interference on the LTE performance.