Advances in video technologies combined with increased usage of synthetic video artifacts even in natural video scenes may cause problems in subjective perception of quality. In this paper investigation is done on how subjective quality assessment scores depend on technical specifications of video interface (YPbPr, YCbCr and YIQ) and video content containing diverse synthetic video artifacts. Single Stimulus (SS) and Simultaneous Double Stimulus (SDS) subjective quality assessment methods were used and results compared. It was also revealed that SDS method allows better differentiation of subjective quality. This result agrees well with statistics obtained from crowd-based questionnaires used in separate study where most observers preferred SDS as a simpler and more comfortable method compared to SS method.