In this paper, we present the characterization results of an optimized 4.6 GHz frequency synthesizer ASIC targeted for miniature atomic clock applications. Fabricated into a 130 nm RF CMOS process, the circuit occupies an active area of 2 mm2 and consumes 15 mW of power. The measured phase noise is about −85 dBc/Hz in the range of 2 kHz to 100 kHz frequency offset from the carrier. The circuit was used as RF synthesizer in an experimental cesium atomic clock setup. The obtained clock stability of 5×10−11 at τ = 1 second corresponds to the stability obtained with a laboratory synthesizer on the same setup, and is limited by the signal-to-noise ratio of the detected CPT signal. The theoretical stability limit due to the ASIC phase noise is 2×10−11 τ −1/2, which is not limiting the measured clock stability.