In this contribution we will present our research activities recently developed at Roma Tre University in the field of plasmonic nanoparticles for biosensing applications. We show several innovative sensing platforms, operating in the visible and near-infrared frequency regime. The contribution of our group regards to the electromagnetic modeling of such nanoparticles and their applications for the analysis and recognition of organic compounds. Numerical results, performed by full-wave simulations, show as the sensors can be used for the recognition of different organic compounds and their concentrations in a highly accurate and sensitive way.