No consensus standard exists for estimating annual conversion efficiency of DC-DC converters or power optimizers in photovoltaic (PV) applications. The performance benefits of PV power electronics including per-panel DC-DC converters depend in large part on the operating conditions of the PV system, along with the performance characteristics of the power optimizer itself. This work presents a case study of three system configurations that take advantage of the capabilities of DC power optimizers. Measured conversion efficiencies of DC-DC converters are applied to these scenarios to determine the annual weighted operating efficiency. A simplified general method of reporting weighted efficiency is given, based on the California Energy Commission's CEC efficiency rating and several input/output voltage ratios. Efficiency measurements of commercial power optimizer products are presented using the new performance metric, along with a description of the limitations of the approach.