In this paper, a high-speed digital system based on DM6437 is designed and implemented for video image processing by signal integrity simulation and analysis. The paper discusses systematically the generation mechandism of reflection and crosstalk, and accomplishes the modeling and simulation of the key transmission line by the SigXP and the constrain manager (CM) tools in Cadence. According to the simulation results, some methods for suppressing reflection and crosstalk, reasonable topology and traces are given. At last, experimental results show that the hardware of the system is stable and the algorithm is effective.