In this paper, we summarize our recent research work on two types of optical fiber sensors: long distance sensor and biomedical sensor. For long distance sensing, we demonstrated our 150-km long distance fiber Bragg Grating (FBG) temperature and vibration sensor system and Brillouin optical time domain analysis distributed sensor system. For biomedical sensing, we demonstrated our microbend fiber sensors for measurements of breathing rate/heat rate and Ballistocardiogram waveform. A new sensor for patient's breathing measurement by using fiber loop ringdown spectroscopy is also introduced.