Pursuing 2020 and 2050 energy and emission goals also the large-scale research facilities must reduce energy consumption and contribution to greenhouse gas (GHG) emission, as well as behaving like good citizens of the smart grid. These new requirements are currently being integrated in the design process of these facilities. Hence, extensive verifications and tests must be carried out before a facility with very heavy power demand is deployed into the grid. In particular, how it impacts the regional grid and how the regional grid impacts the facility. In this paper, we present the simulation results of these mutual impacts, based on the real world project of a spallation source. As a meaningful contribution, the uncertainty quantification is applied to handle with stochastic nature of renewable energy in this project, by RTDS simulation and Monte Carlo simulation together.