Human immunodeficiency virus (HIV) / Acquired immune deficiency syndrome (AIDS) is a major global health problem. It is the greatest threat to the reconstruction and development of South Africa. Advances in Information and Communication Technology (ICTs) have facilitated development of medical expert systems. They have proved their usefulness since they can provide; precise, quick and inexpensive consultation. Advisory expert system is seen as enhancement tool in providing home-base care to people living with HIV/AIDS. In this paper we describe the development of advisory expert system used by HIV-patients in Gugulethu to self-manage the HIV-related symptoms they experienced. We also present the results obtained at the end of the research.