Nanopatterning using near-field optics has shown great potential for industrial applications. A novel application of water droplets to this technology is proposed in this study. With a hydrophobic layer and controlled substrate temperature, a layer of randomly distributed water droplets with a high contact angle is formed on the substrate. These liquid droplets can be used as lenses to enhance the laser intensity at the bottom of the droplets. As a result, nanoscale holes can be formed on the substrate by laser ablation. We have fabricated holes with a diameter of 500nm at the substrate temperature of 12°C. The depth of the holes ranges from 0.1µm to 0.9µm, depending on the diameter of droplets.