To have a full description of the fatigue behavior of nano-silver sintered lap shear joint, isothermal low cycle mechanical fatigue test was conducted in a systematic manner over a wide range of temperatures (25 to 325°C) with the shear strain amplitude set at different values. The low cycle fatigue behavior of the sintered lap shear joint was found to be strongly dependent on test temperature. To investigate the temperature affection on fatigue life, a new life prediction model based on Basquin model was developed by transforming the fatigue strength exponent bth and fatigue strength coefficient, εfth as a function of temperature rather than numerical constants.