Recently, the R&D and applications of M2M systems are booming in China, especially after it is written in the 2010 Government Work Report. In this paper, the R&D works of wireless eHealth (WeHealth) are overviewed, the concept of which was proposed by our group in 2005. Some key techniques of WeHealth system are discussed, and some practices based on the concept of WeHealth are introduced. Besides, a recent WeHealth pilot trial on chronic disease monitoring is also introduced, which is reported as “The First Wireless Healthcare Chronic Disease Monitoring Project in China Based on Internet of Things Technology”. There are 30 community hospitals up to now applying our WeHealth blood pressure monitoring system for chronic disease management. The practical data clearly demonstrate the effectiveness of our WeHealth system in hypertension disease control.